Further Evidence of Clinical Inertia in T2D Management

Further Evidence of Clinical Inertia in T2D Management

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From ConsultQD

Clinical practice guidelines recommend frequent monitoring of HbA1c levels in patients with uncontrolled type 2 diabetes. This means checking patients every three months and escalating antihyperglycemic therapies to reach glycemic targets.

Recent Cleveland Clinic research highlights a high level of clinical inertia, meaning a failure to intensify therapy when the need is clinically indicated. A team at Cleveland Clinic looked at electronic medical record data of more than 7,300 patients with type 2 diabetes with an HbA1c value of ≥ 7 percent on a stable regimen of two oral anti-diabetic agents for at least 6 months (from 2005-2016). After systematic review, it was found that median time to treatment intensification after HbA1c was above target was longer than one year. Of great concern to the researchers was the finding that even for patients with an HbAc1 of ≥ 9 percent, therapy was not intensified in 44 percent of patients.

The team concluded that the data identifies a pervasiveness of clinical inertia for the management of type 2 diabetes in the real-world clinical practice setting.

According to lead study author Kevin Pantalone, MD, of Cleveland Clinic’s Endocrinology & Metabolism Institute, “Short of a patient reporting non-adherence to their existing regimen of diabetes therapies, it is hard to imagine a reason why treatment intensification was not observed more frequently, when indicated, particularly in patients with an A1C ≥ 9 percent. In general, if intensification does not occur, the A1C can be expected to stay the same or get worse, it is not magically going to get better.”

Dr. Pantalone added, “It is important for providers to recognize the need to intensify therapy when a patient’s A1C is not at goal, and this includes considering not only adding additional anti-diabetic therapies, but also non-pharmacologic forms of interventions, such as nutrition consultations or referrals to certified diabetes educators.”

The team plans to do further analysis of the research to look at patterns in the changes in HbA1c values according to the types of interventions received

See the full manuscript at Diabetes Care  

This study was funded by Novo Nordisk, Inc. Dr. Pantalone reports receiving consulting fees from Novo Nordisk, Merck, and Sanofi within the past 12 months. Dr. Pantalone has also received research support from Novo Nordisk and Merck within the past 12 months, and he has received speaker honoraria as a member of the AstraZeneca, Novo Nordisk and Merck speaker bureaus within the past 12 months.

 

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