Spin-Off Companies



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  • ART SARL (Arterial Remodeling Technologies)

    Technology: Biodegradable polymeric stent. Joint development of CCF and Centre National de la Recherche Scientifique, The University of Montpellier, and University Rene Descartes.
    Year established: 2002
    Stage: Series A
    Location: France
    Contact Information: mvanderleest@art-stent.com


  • Autonomic Technologies

    Technology: Autonomic nervous system stimulation for pulmonary and headache disorders.
    Year established: 2007
    Stage: Series B
    Location: Redwood City/ Cleveland
    Contact Information: Contact John Smith for more information: bpless@autonomictechnologies.com


  • Axiomed Spine Corporation

    Technology: Axiomed is developing the next generation of artificial lumbar disc replacement technology. Although the Company was not founded based on the Cleveland Clinic Technology, Drs. Benzel and Lieberman have been instrumental in helping the Company to refine its technology.
    Year established: 2001
    Stage: All Stages
    Location: Cleveland
    Contact Information: Contact Pat McBrayer for more information: PMcBrayer@axiomed.com


  • Cancer Genetics Technology: Developing genomic-based, oncology tests and services.
    Year established: 2013
    Stage: Public/Acquired
    Location: Rutherford, NJ
    Contact Information:


  • CardioNomic Technology: Neurostimulation for cardiac contractility.
    Year established: 2007
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Jon Heavey for more information: heaveyj@ccf.org


  • CBL

    Technology: Clinical-stage biotechnology company with a focus on oncology and orphan drug development.
    Year established: 2003
    Stage: Public/Acquired
    Location: Buffalo, NY
    Contact Information: Contact Rachel Levine for more information: rlevine@cbiolabs.com


  • Clear Catheter Systems

    Technology: Advanced anti-clogging drainage systems.
    Year established: 2007
    Stage: Series B
    Location: Cleveland
    Contact Information: Contact Ed Boyle, M.D. for more information: emb@clearcatheter.com


  • Cleveland Diagnostics Technology: Diagnostic test for prostate cancer
    Year established: 2013
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Jeff Marshall for more information: marshaj@ccf.org


  • Cleveland Heart

    Technology: Artificial heart technologies
    Year established: 2007
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Franz Kellar for more information: fkellar@clevelandheart.com


  • Cleveland HeartLab, LLC

    Technology: Cardiovascular diagnostics and specialty reference lab
    Year established: 2009
    Stage: Series B
    Location: Cleveland
    Contact Information: jorville@clevelandheartlab.com


  • Custom Orthopaedic Solutions

    Technology: Tools to improve orthopaedic surgical outcomes.
    Year established: 2011
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact: Peter O'Neill for more information: oneillp@ccf.org


  • Enforcer eCoaching

    Technology: Email-based health and wellness coaching programs.
    Year established: 2010
    Stage: Series A
    Location: Cleveland
    Contact Information: info@youdocs.com


  • Enspire Technology: Deep Brain Stimulation (DBS) therapy to treat stroke, traumatic brain injury and Parkinson’s disease.
    Year established: 2011
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Sam Kiderman for more information: kiderms@ccf.org


  • Explorys

    Technology: Patient database / EMR technology
    Year established: 2009
    Stage: All Stages
    Location: Cleveland
    Contact Information: Contact Stephen Mchale for more information: stephen.mchale@explorysmedical.com


  • flexlife

    Technology: Remote patient monitoring tools
    Year established: 2012
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Sam Kiderman for more information: kiderms@ccf.org


  • i360

    Technology: Healthcare solutions and medical device innovation company.
    Stage: All Stages
    Location: Dublin
    Contact Information: info@i360medical.ie


  • iComet

    Technology: Software platform to evaluate cognitive and motor functions
    Year established: 2011
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Frank Carruba for more information: fcarruba@icomettechnologies.com


  • Image IQ

    Technology: Biomedical Imaging and Analysis
    Year established: 2010
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Tim Kulbago for more information: tkulbago@image-iq.com


  • infuseon Technology: Convection enhanced drug delivery catheter
    Year established: 2011
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Bill Kolosi for more information: kolosiw@ccf.org


  • Ion-vac Technology: Silver ion wound healing device.
    Year established: 2012
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Joe Rich for more information: richj2@ccf.org


  • iVHR Technology: Interactive Visual Health Record software.
    Year established: 2012
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Sam Rizk for more information: srizk@ivhr.com


  • Juventas Therapeutics

    Technology: Biopharmaceuticals that recruit stem cells to repair ischemic tissue.
    Year established: 2006
    Stage: Series B
    Location: Cleveland
    Contact Information: Contact Rahul Aras, Ph.D. for more information: rahul@juventasinc.com


  • Merlot Orthopedix

    Technology: Bone anchorage systems.
    Year established: 2004
    Stage: Pre-Seed B
    Location: Cleveland
    Contact Information: Contact Sam Kiderman for more information: kiderms@ccf.org


  • NaviGate Cardiac Structures Technology: Transctheter Mitral Valve
    Year established: 2011
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Mary Kander for more information: kanderm@ccf.org


  • Navis Medical

    Technology: Side-Entry Torquer used on any standard guidewire
    Year established: 2007
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Bill Kolosi for more information: kolosiw@ccf.org


  • OptoQuest Technology: Diagnosis and therapeutic ophthalmic devices
    Year established: 2008
    Stage: Pre-Seed
    Location: Cleveland
    Contact Information: Contact Neema Mayhugh, Ph.D. for more information: mayhugn@ccf.org


  • Perfusion Solutions Technology: Heart Pumps
    Year established: 2008
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Stephan Weber for more information: sweber@perfsolinc.com


  • PeriTec Biosciences Technology: Peritoneum lined peripheral vascular products.
    Year established: 2002
    Stage: Series B
    Location: Cleveland
    Contact Information: Contact Timur Sarac, M.D. for more information: saract@ccf.org


  • Renovo Neural

    Technology: Drug development specializing in therapies for Multiple sclerosis
    Year established: 2008
    Stage: Pre-Seed A
    Location: Cleveland
    Contact Information: Contact Satish Medicetty for more information: smedicetty@renovoneural.com


  • Talis Clinical Technology: Talis Clinical commercializes an Anesthesia information management system that has been used in Cleveland Clinic operating rooms since 2010
    Year established: 2012
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Gary Collister for more information: fingerg@ccf.org


  • Tolera Therapeutics Technology: Immune modulation via novel therapies.
    Year established: 2006
    Stage: Pre-Seed
    Location: Cleveland
    Contact Information: kiderms@ccf.org

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    Spin-Offs

    Innovations has facilitated several Cleveland Clinic Spin-Offs over the last decade. Click here to see our current portfolio.

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