Spin-Off Companies



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  • ADEO

    Technology: ADEO is the online exchange dedicated to innovating healthcare by bringing world-class solutions to market. We believe that having the right tools is a must in order to improve patient lives and transform healthcare delivery. That’s why ADEO offers a convenient way to shop for the solutions you need in order to tackle a variety of clinical and business challenges.
    Year established: 2014
    Stage: Series A
    Location: Cleveland, Ohio
    Contact Information: www.onadeo.com


  • ART SARL (Arterial Remodeling Technologies)

    Technology: Biodegradable polymeric stent. Joint development of CCF and Centre National de la Recherche Scientifique, The University of Montpellier, and University Rene Descartes.
    Year established: 2002
    Stage: Series A
    Location: France
    Contact Information: mvanderleest@art-stent.com


  • Autonomic Technologies

    Technology: Autonomic nervous system stimulation for pulmonary and headache disorders.
    Year established: 2007
    Stage: Series C and Later
    Location: Redwood City/ Cleveland
    Contact Information: bpless@autonomictechnologies.com


  • Axiomed Spine Corporation

    Technology: Axiomed is developing the next generation of artificial lumbar disc replacement technology. 
    Year established: 2001
    Stage: Series C and Later
    Location: Cleveland
    Contact Information: PMcBrayer@axiomed.com


  • Cancer Genetics Technology: Developing genomic-based, oncology tests and services.
    Year established: 2013
    Stage: Public/Acquired
    Location: Rutherford, NJ
    Contact Information:


  • CardioMEMS

    Technology: Implantable wireless pressure sensors
    Year established: 2000
    Stage: Public/Acquired
    Location: Atlanta
    Contact Information:


  • CardioNomic Technology: Neurostimulation for cardiac contractility.
    Year established: 2007
    Stage: Series A
    Location: Cleveland
    Contact Information: heaveyj@ccf.org


  • CBL

    Technology: Clinical-stage biotechnology company with a focus on oncology and orphan drug development.
    Year established: 2003
    Stage: Public/Acquired
    Location: Buffalo, NY
    Contact Information: rlevine@cbiolabs.com


  • ClearFlow, Inc.

    Technology: ClearFlow, Inc. is an Anaheim, CA based company which makes the PleuraFlow® Active Clearance Technology™ System, a new standard of care for post operative cardiac surgery wound drainage.
    Year established: 2007
    Stage: Series B
    Location: Anaheim, CA
    Contact Information: emb@clearcatheter.com


  • Cleveland Diagnostics Technology: Diagnostic test for prostate cancer
    Year established: 2013
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Jeff Marshall for more information: marshaj@ccf.org


  • Cleveland Heart

    Technology: Artificial heart technologies
    Year established: 2007
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Franz Kellar for more information: fkellar@clevelandheart.com


  • Cleveland HeartLab, LLC

    Technology: Cardiovascular diagnostics and specialty reference lab
    Year established: 2009
    Stage: Series B
    Location: Cleveland
    Contact Information: jorville@clevelandheartlab.com


  • Custom Orthopaedic Solutions

    Technology: Tools to improve orthopaedic surgical outcomes.
    Year established: 2011
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact: Peter O'Neill for more information: oneillp@ccf.org


  • Enforcer eCoaching

    Technology: Email-based health and wellness coaching programs.
    Year established: 2010
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Enspire Technology: Deep Brain Stimulation (DBS) therapy to treat stroke, traumatic brain injury and Parkinson’s disease.
    Year established: 2011
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Esperion Therapeutics

    Technology: Therapies for the treatment of patients with elecated levels of low density lipoprotein cholesterol (LDL-C) and other cardiometabolic risk factors
    Stage: Public/Acquired
    Location: Ann Arbor, MI
    Contact Information:


  • Explorys

    Technology: Patient database / EMR technology
    Year established: 2009
    Stage: Series C and Later
    Location: Cleveland
    Contact Information: Contact Stephen Mchale for more information: stephen.mchale@explorysmedical.com


  • flexlife

    Technology: Remote patient monitoring tools
    Year established: 2012
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • i360

    Technology: Healthcare solutions and medical device innovation company.
    Stage: All Stages
    Location: Dublin
    Contact Information: info@i360medical.ie


  • iComet

    Technology: Software platform to evaluate cognitive and motor functions
    Year established: 2011
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Frank Carruba for more information: fcarruba@icomettechnologies.com


  • Image IQ

    Technology: Biomedical Imaging and Analysis
    Year established: 2010
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Tim Kulbago for more information: tkulbago@image-iq.com


  • infuseon Technology: Convection enhanced drug delivery catheter
    Year established: 2011
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Bill Kolosi for more information: kolosiw@ccf.org


  • Ion-vac Technology: Silver ion wound healing device.
    Year established: 2012
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Joe Rich for more information: richj2@ccf.org


  • iVHR Technology: Interactive Visual Health Record software.
    Year established: 2012
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Sam Rizk for more information: srizk@ivhr.com


  • Juventas Therapeutics

    Technology: Biopharmaceuticals that recruit stem cells to repair ischemic tissue.
    Year established: 2006
    Stage: Series B
    Location: Cleveland
    Contact Information: Contact Rahul Aras, Ph.D. for more information: rahul@juventasinc.com


  • Merlot Orthopedix

    Technology: Bone anchorage systems.
    Year established: 2004
    Stage: Series B
    Location: Cleveland
    Contact Information:


  • NaviGate Cardiac Structures Technology: Transctheter Mitral Valve
    Year established: 2011
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Navis Medical

    Technology: Side-Entry Torquer used on any standard guidewire
    Year established: 2007
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Bill Kolosi for more information: kolosiw@ccf.org


  • OptoQuest Technology: Diagnosis and therapeutic ophthalmic devices
    Year established: 2008
    Stage: Pre-Seed
    Location: Cleveland
    Contact Information:


  • Perfusion Solutions Technology: Heart Pumps
    Year established: 2008
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Stephan Weber for more information: sweber@perfsolinc.com


  • Renovo Biosciences Technology: Contract research organization and 3DEM services focusing on multiple sclerosis therapies
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Renovo Neural

    Technology: Drug development specializing in therapies for Multiple sclerosis
    Year established: 2008
    Stage: Series A
    Location: Cleveland
    Contact Information: Contact Satish Medicetty for more information: smedicetty@renovoneural.com


  • Rindex Medical Technology: Arrhythmia prediction technology
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Shield Biotech Technology: Breast Cancer Vaccine
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • SironRX Therapeutics Technology: Wound repair
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Talis Clinical

    Technology: Talis Clinical commercializes an Anesthesia information management system that has been used in Cleveland Clinic operating rooms since 2010
    Year established: 2012
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • Tolera Therapeutics Technology: Immune modulation via novel therapies.
    Year established: 2006
    Stage: Series B
    Location: Cleveland
    Contact Information: kiderms@ccf.org


  • ValveXchange

    Technology: Two-part heart valve including an exchangeable bioprosthetic tissue leaflet set
    Year established: 2001
    Stage: Series A
    Location: Colorado
    Contact Information: Larry Blankenship lblankenship@valvexchange.com


  • XDI Healthcare Technology: Software platform for frontline staff to self-innovate
    Stage: Series A
    Location: Cleveland
    Contact Information:


  • YouDocs Beauty Technology: Social media site for medical, chemical and psychological aspects of human beauty, style and attraction
    Year established: 2010
    Stage: Public/Acquired
    Location: Cleveland
    Contact Information:

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    Spin-Offs

    Innovations has facilitated several Cleveland Clinic Spin-Offs over the last decade. Click here to see our current portfolio.

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