#2 Designer Therapeutics Using Selective Receptor Antagonists

Overview

Novel therapeutics have been created to block receptor activation that leads to improved patients' outcomes. Examples include therapeutics that: block the peripheral side effects-such as constipation and nausea-of opioid medications for pain which can adversely affect patients and lengthen hospitalizations; and control the body's stress response to mediate eating and smoking.

There have been some setbacks in this field, with the recent withdrawal of an SRA-obesity drug from U.S. market trials, and the suspension of the drug in the EU because of a poor risk/benefit ratio in clinical practice.

Where Are They Now

Novel therapeutics have been created to block receptor activation that leads to improved patient outcomes. Examples include therapeutics that block the peripheral side effects-such as constipation and nausea-of opioid medications for pain, which can adversely affect patients and lengthen hospitalizations; and control of the body's stress response to mediate eating and smoking. Research in this area continues with new trials being conducted in multiple areas, such as treatment of muscle and bone disorders.

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