Therapeutics & Diagnostics Companies

Alios BioPharma

Founded: 2006
Location: San Francisco, CA
Status: IPO
Amount Seeking:

About the Company: In November of 2014, Johnson & Johnson (NYSE: JNJ) announced the completion of the acquisition of Alios BioPharma, Inc., a privately held clinical stage biopharmaceutical company focused on developing therapies for viral diseases. Alios BioPharma is now part of the infectious diseases therapeutic area of the Janssen Pharmaceutical Companies of Johnson & Johnson.  The acquisition includes Alios BioPharma’s portfolio of potential therapeutics for viral infections with the promising compound AL-8176, an orally administered antiviral therapy currently in Phase 2 studies for the treatment of infants with respiratory syncytial virus (RSV).  RSV is the last of the major pediatric diseases that currently has no effective therapy.  The acquisition also includes two early-stage compounds for hepatitis C (HCV).

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Cancer Genetics

Founded: 2013
Location: Rutherford, NJ
Status: IPO
Amount Seeking:

About the Company: Cancer Genetics, Inc. (CGI) is a leader in the field of personalized medicine, offering diagnostic products and services that enable precision medicine in the field of oncology.

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Centerline Biomedical

Founded: 2014
Location: Cleveland, OH
Status: Seed
Amount Seeking: $4M

About the Company: Centerline Biomedical is developing an innovative system to navigate catheters and guide wires (and ultimately devices) in the 3D anatomy of vascular disease patients. This system will empower surgeons to perform safer, more accurate, and more efficient endovascular procedures.

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Cleveland BioLabs, Inc.

Founded: 2003
Location: Buffalo, NY
Status: IPO
Amount Seeking:

About the Company: Cleveland BioLabs, Inc. (NASDAQ: CBLI) is an innovative biopharmaceutical company developing novel approaches to activate the immune system and address serious medical needs. Our proprietary platform of toll-like immune receptor activators has applications in radiation mitigation, oncology immunotherapy, and vaccines. We combine our proven scientific expertise and our depth of knowledge about our products’ mechanisms of action into a passion for developing drugs to save lives. Our proprietary drug candidates act via unique mechanisms that are designed to kill cancer and protect healthy cells.

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Cleveland Diagnostics

Founded: 2013
Location: Cleveland, OH
Status: Series A
Amount Seeking: $5M

About the Company: Cleveland Diagnostics is developing a breakthrough technology to discover new class of diagnostics tests with high sensitivity and specificity for many cancers – early on, when cancer is still curable

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Cleveland HeartLab, LLC

Founded: 2009
Location: Cleveland, OH
Status: Series D
Amount Seeking:

About the Company: Cleveland HeartLab offers innovative, scientifically proven, and medically relevant biomarkers that are predictive of cardiovascular risk. We offer inflammatory and other advanced biomarker testing that practitioners from across North America, Europe and Asia use in the management and prevention of heart disease. Our novel biomarker technologies are offered through our CAP-accredited and CLIA-certified clinical reference laboratory. We also run a research and development laboratory where next-generation cardiovascular disease biomarkers are being developed for use through our clinical laboratory. This valuable pipeline of tests is part of an exclusive intellectual property portfolio that targets large, under-addressed markets. Additionally, Cleveland Heartlab is ISO 13485 certified and the exclusive providers of Universal CardioMPO™ kits.

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Esperion

Founded: 2010
Location: Ann Arbor, MI
Status: Acquired
Amount Seeking:

About the Company: Esperion is a pharmaceutical company focused on developing and commercializing first-in-class, oral, low-density lipoprotein cholesterol (LDL-C) lowering therapies for the treatment of patients with elevated LDL-C.

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Infuseon Therapeutics, Inc.

Founded: 2012
Location: Cleveland, OH
Status: Seed
Amount Seeking: $5M

About the Company: Infuseon Therapeutics, Inc. was founded in 2012 by  Cleveland Clinic for to purpose of developing  a unique therapeutic delivery device via its patented Cleveland Multiport Catheter™ system. This first-ever multiport catheter was  designed by a neurosurgeon from Cleveland Clinic's Brain Tumor and NeuroOncology Center to more effectively deliver life-saving drugs to  patients at the site of their disease.
 
Parker-Hannifin Corporation, a global leader in motion and control technologies, is collaborating with Infuseon to combine and enhance the medical design, development, and manufacturing expertise of the company.

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Juventas Therapeutics

Founded: 2006
Location: Cleveland, OH
Status: Series B
Amount Seeking:

About the Company: Juventas Therapeutics is a private, clinical stage biotechnology company developing novel non-viral gene therapies that activate natural processes to repair the body. Their product candidate, JVS-100, is a non-viral gene therapy that expresses stromal cell-derived factor-1, or SDF-1, a naturally occurring signaling protein that has been shown to recruit the body’s own stem cells and promote tissue repair in a broad range of disease states. Juventas’ therapeutic approach is based on research originating at the Cleveland Clinic. Juventas is currently enrolling a Phase 2b study in patients with advanced peripheral artery disease.

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NeuroTherapia

Founded: 2015
Location: Cleveland, OH
Status: Seed
Amount Seeking: Seeking Series A

About the Company: NeuroTherapia is a private, pre-clinical stage biotechnology company developing novel therapies that decrease the neuroinflammation which plays a critical role in a wide spectrum of diseases such as neuropathic pain and Alzheimer’s disease. NeuroTherapia has secured seed funding from the Ohio Biovalidation Fund and Alzheimer Drug Discovery Foundation.

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