Animal studies have been completed demonstrating the ability of AMHR2 vaccination to significantly inhibited growth of both autochthonous and transplantable ovarian tumors and dramatically increase overall survival. In addition, combining AMHR2 with a PD-L1 inhibitor enhanced the tumor inhibiting effects. Vaccination of mice was shown to be very safe, only transient oophoritis was observed with no effect on fertility.
Experimental Ovarian Cancer Vaccine Shows Promise in Mice
Primary Immunoprevention of Epithelial Ovarian Carcinoma by Vaccination against the Extracellular Domain of Anti-Müllerian Hormone Receptor II.
Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II.