Animal studies have been completed demonstrating the importance of PCSK6 and corin in heart disease and hypertension through knock out experiments while cell systems have demonstrated that transfection of a plasmid expressing PCSK6 can increase corin activation. More recent data has shown that corin activation by PCSK6 occurs extracellularly. Animal studies using recombinant PCSK6 are awaiting funding.
PCSK6-mediated corin activation is essential for normal blood pressure
Functional analysis of corin protein domains required for PCSK6-mediated activation.