Closed-Loop Optimization of Neuromodulation Therapies


What is it? What does it do?

Neurostimulation is used to treat neurological disorders including stroke Parkinson’s disease, depression, and epilepsy. For deep brain stimulation therapies, functional neuroimaging techniques are used to target the delivery of devices and optimize these stimulation therapies. This is accomplished by observing a patient’s brain activity while undergoing neurostimulation and assessing the efficacy of the stimulation by comparing the patient’s brain activity to that of other patients who had receiving the same therapy effectively. The process assesses the results and adjusts the stimulation accordingly to ensure efficacy.

Why is it better?

Current Methods are insufficient due to inaccuracy of stimulation parameters, and efficacy assessments can be subjective. An example for chronic pain assessment would involve asking the patient to rate their pain on a 0-10 point scale. By instead relying on the data derived from neuroimaging, physicians will have access to objective measures of therapy efficacy. This system is also self-correcting, making internal recommendations and adjustments to maximize therapeutic value.

What is its current status?

We have obtained pilot data of DBS cases done in the MRI suite to guide us in understanding the signatures corresponding to good outcomes after DBS.





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